The Next Era of Drug Development
What if we could gather human-relevant data earlier — before first-in-human trials, without patient risk?
We can cure mice of any disease we can imagine.
But when it comes to humans, we’re lost.
To bring a single new drug to market
Failure rate for clinical trials
Time from discovery to clinical approval
We don’t understand human biology because we don’t have a complete picture
Petri dish models are too simple
Petri dish data can’t replicate patient complexity and variability.
Animal biology can’t predict human outcomes
Key differences in physiology, metabolism, and immune response limit the relevance of animal data in drug development.
Clinical trials are Too risky
Patient risk severely limits the data we can collect from clinical trials.
A paradigm shift in drug development is gathering momentum—from animal models to human systems
Legacy animal model based approaches
Limited translatability to human biology
Animal models
Emerging alternatives
Fragmented with limited solutions
Organ-on-chip
Organoids
IPSC derived models
Integrated Human Data Platform
More predictive, faster insights, and clinically relevant
Scientific and regulatory limits, plus rising costs create pressure for integrated, scalable human systems
Cost pressures
Faster timelines to IND
Faster timelines to IND/NDA
Ethical / ESG pushback on animal use
Human Data Trials are the next frontier
and donated human organs revived on perfusion are the Rosetta Stone
How Human Data Trials Work
Purpose
Work together with Revalia to define your Human Data Trial area of interest. From discovery to ADME/Tox, biodistribution, and efficacy, Revalia’s Phase 0 Trials can help elucidate your most pressing pre-clinical questions.
Contact UsTrial design
Go through technical workshops with Revalia to get to your preferred trial design and establish your key endpoints.
Donor enrollment
Once you’ve worked with Revalia to finalize a trial design, Revalia then engages our OPO partners to screen donors that would be appropriate to enroll, making sure we maximize the gift with every donation.
Trial execution
Revalia executes the trial with clinical precision, ensuring all relevant samples and data are captured with high fidelity.
Data generation
Revalia processes samples to collect rich multi-modal data spanning molecular signatures, imaging and histopathology, and organ-level functional outputs.
Data analysis & interpretation
Revalia analyzes and synthesizes trial findings to extract meaningful biological and translational insights.
Strategic decision making
Our partners then use the results to determine whether to advance the program, modify the approach, or deprioritize based on real human tissue response.
Revalia makes tomorrow’s Human Data Stack possible today by
Sourcing the data that only donated organs that can generate
Providing the software infrastructure to ingest and manage human data
Incorporating collaborative tools to break down the institutional barriers that hold back research on human data
